Part 1: The Hoosier Sophisticate Show - First Hour (Approx. 0:00 - 30:00)
• 0:00 - 1:00: Opening & Philosophical Introduction
◦ A contemplative start questioning the nature of reality, likening the world to an amusement park ride.
• 1:00 - 3:00: Show Introduction & Welcomes
◦ Hosts welcome listeners, mention the broadcast time (Thursday nights 9-11) and station (KLIS 590 a.m. in St. Louis), and provide online listening options via luinfo.com.
◦ Acknowledgments to "North" and an introduction of the show's goal: positive change through laughter, jokes, and discussing the nature of reality.
• 3:00 - 4:45: Upcoming Segments & Sponsors
◦ Tease the upcoming DNA-based interview with Joshua Wahba from Dynamic DNA at 9:15.
◦ Promotion for North dispensaries, including the "Canna Cup and Music Festival" on August 30th at the Jeffco Fairgrounds, with a contest for VIP passes.
◦ Discussion about finding a trusted dispensary and personal preferences, comparing it to a favorite gas station.
• 4:45 - 6:45: Audience Interaction & Humorous Anecdotes
◦ Shout-out to the text line (314-590-3770) and engaging with texters.
◦ Humorous stories, including an anecdote about the 9/11 anniversary and past experiences with unsolicited drug offers.
◦ Discussion about a son's recent encounter with strangers offering "free drugs" and the contrast with past drug-awareness campaigns.
◦ Reminiscing about smoking cannabis in school and earlier experiences with drugs.
• 6:45 - 29:30: Interview with Joshua Wahba from Dynamic DNA Labs
◦ 6:45 - 8:00: Introduction of Joshua Wahba
▪ The hosts introduce Joshua Wahba, Vice President of Operations for Dynamic DNA Labs, to discuss DNA and its connection to psychedelic science.
◦ 8:00 - 14:00: DNA Testing Capabilities
▪ Josh explains Dynamic DNA Labs as a high-complexity molecular pathology lab doing advanced DNA testing.
▪ He details pharmacogenomics (personalized medicine), which determines how individuals metabolize medications, optimizing efficacy and reducing guesswork.
▪ He then introduces their unique test applying the same science to psychoactive compounds/psychedelics, focusing on harm reduction, predicting experiences, and choosing the right compound and dosage (e.g., ketamine vs. psilocybin) based on genetic makeup.
▪ Discussion on the ethical lines of genetic screening, contrasting it with the lab's focus on predispositions and optimizing health.
▪ Explanation of Polygenic Risk Score (PRS) for cancer and disease predisposition screening, and the difference between clinical and non-clinical tests.
◦ 14:00 - 18:30: Deep Dive into Psychedelic Screening & Genes
▪ Detailed explanation of how the HTR2A gene affects psilocybin sensitivity, illustrating how genetic profiles can predict the intensity of psychedelic effects.
▪ Clarification that DNA does not change, and the tests look at gene activity and receptor sensitivity, not the effects of other medications on a separate metabolic pathway.
◦ 18:30 - 21:00: Dynamic DNA Labs Information & Discount
▪ How listeners can learn more or contact Dynamic DNA Labs (dynamicdnalabs.com).
▪ Exclusive discount code "Josh15" for 15% off for listeners.
◦ 21:00 - 23:00: Ancestry Testing
▪ Josh explains why Dynamic DNA Labs no longer offers ancestry testing, citing larger companies with more extensive databases and their commitment to private, non-shared data.
◦ 23:00 - 27:00: Remarkable Learnings & Cannabis DNA Panel
▪ Josh shares insights from their cannabis DNA panel, which provides personalized terpene recommendations (energizing/relaxing) and analyzes minor cannabinoids beyond THC and CBD for optimal experience and health benefits.
▪ Discussion of the endocannabinoid system and how the psychedelic DNA panel serves as a harm reduction tool and helps explain personal experiences.
▪ The host (Steve) expresses enthusiasm for the endocannabinoid system and terpenes, questioning traditional indica/sativa classifications.
◦ 27:00 - 29:30: Terpene Profiles & Dispensary Interaction
▪ Discussion on how terpene profiles influence not just taste and smell, but also medicinal benefits.
▪ Josh highlights the DNA dosing card from their cannabis panel, which empowers consumers to guide budtenders in choosing products based on specific terpene profiles and needs.
• 29:30 - 30:00: Psychedelic Freedom Conference
◦ Josh announces the Psychedelic Freedom Conference in Springfield on September 16th, focusing on psychedelic healing, science, and community connection.
◦ Keynote speaker: Former Missouri House Representative Ron Hicks, who transformed after psilocybin-assisted therapy.
◦ Emphasis on education, awareness, and fostering inclusive spaces for healing and transformation.
Part 2: The Hoosier Sophisticate Show - Second Hour (Approx. 30:00 - 60:00)
• 30:00 - 30:30: Transition & Teaser
◦ The hosts tease the second hour's topic: the nature of reality.
◦ A reminder of the Dynamic DNA Labs discount code "Josh15".
• 30:30 - 31:30: Second Hour Opening & Contact Info
◦ Welcome back to the second hour, reiterating radio frequency and online presence.
◦ Contact information for texting in.
• 31:30 - 34:00: Humorous Call Segment
◦ A joke segment about calling random contacts from their phone live on air to prank them.
• 34:00 - 37:30: Sponsor Reads & Announcements
◦ Live reads for sponsors, including "Rose Extermination" (family-owned business for pests).
◦ A humorous mention of the quality of sponsor reads.
• 37:30 - 49:30: Experience at Iskcon (Hare Krishna Temple)
◦ The hosts recount their recent, "unreal" visit to the International Society for Krishna Consciousness (Iskcon) for Balarama's birthday.
◦ Details of the experience: removing shoes, chanting, drums, bells, and a welcoming atmosphere.
◦ Steve's comparison to Catholic church experiences and the interactive nature of the service, including a theological lecture.
◦ A funny anecdote about Steve's question during the lecture and the theme of happiness being futile in this existence compared to the "ocean" of future bliss.
◦ Reflection on finding happiness amidst difficult experiences and the relief of anxiety around death.
◦ Description of the ecstatic dancing and communal singing of Krishna's name.
◦ Humorous moments during the service, including mishearing "cow herd boyfriends" and chuckling during a description of a "brown god".
◦ Discussion of the music, including a drummer with an unusual time signature and the arrival of a "Caribbean style" drummer.
◦ The welcoming nature of the community and the vegetarian meal served.
• 49:30 - 58:30: The Nature of Reality, AI & Technology's Impact
◦ The main topic of the second hour: the nature of reality in the age of video, pictures, and Artificial Intelligence (AI).
◦ Concerns about AI's ability to create fake content, its impact on information integrity, and the "death of what we know is reality".
◦ Discussion of AI's rapid evolution, including the filtering out of rarely used nouns, leading to a less authentic and more homogenous thought process.
◦ The idea that reality is often "the stories of the winners" and the need to question everything.
◦ The Patriot Act is mentioned as a turning point, trading freedom for comfort and enabling mass data collection.
◦ Critique of modern media consumption, lack of attention span, and the decline of authentic movies.
◦ The hosts ponder if life itself is a "VR headset" or a "video game" like Red Dead Redemption.
◦ Emphasis on living a dynamic personal story and experiencing the world to react to curveballs and build connection.
◦ The concept of AI hallucinations is discussed, comparing it to a "flood of everything" in the brain during psychedelic experiences.
◦ The need to "surrender" in the face of rapidly advancing technology and its implications.
• 58:30 - 60:00: Show Wrap-up & Final Thanks
◦ Concluding remarks, thanking the guest (Josh Wahba from Dynamic DNA Labs) and sponsors (North Dispensaries).
◦ Reminders for the Canna Cup and Music Festival on August 30th.
◦ Final thank yous to the audience, YouTube followers, and encouragement to share the show and follow their Facebook page